Regarding the location of the FITC label and any effects on activity, there is no specific description available on where the FITC label is positioned on FITC-insulin. However, in practice, there are only three potential sites where the FITC can derivatize the insulin. These locations include both of the N-terminal residues, off the free amine, and the Lysine at the 3rd position near the C-terminus of the B-chain.
I3661
Insulin-FITC labeled human
recombinant, expressed in yeast, lyophilized powder
Synonyme(s) :
FITC Insulin, Labeled Human Insulin
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About This Item
Produits recommandés
Produit recombinant
expressed in yeast
Niveau de qualité
Forme
lyophilized powder
solid
Composition
Insulin, ≥75% biuret
Ampleur du marquage
≥1 mol FITC per mol insulin
Conditions d'expédition
dry ice
dry ice
Température de stockage
−20°C
−20°C
Description générale
Insulin is a polypeptide hormone mainly secreted from pancreas when glucose level changes in the plasma. It is an anabolic hormone and enhances the generation of storage substances, for instance glycogen, fat and protein. It also induces glucose uptake by peripheral tissues, thereby controlling glucose levels in the plasma. Its main sites of action are liver, adipose tissue and muscle.[1]
Application
Insulin-FITC labeled human has been used in primary endothelial cells from human adipose tissue microvasculature (HAMEC) to study insulin transcytosis.[2]
Forme physique
Lyophilized powder containing sodium phosphate buffer salts
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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