A6185

Calpain Inhibitor I

≥97% (TLC), powder

• Synonyme(s) : ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Norleu-al
• Formule empirique (notation de Hill) : C₂₀H₃₇N₃O₄
• Numéro CAS: 110044-82-1
• Poids moléculaire : 383.53
• Beilstein: 7656053
• Numéro MDL: MFCD00065505
• Code UNSPSC : 12352200
• ID de substance PubChem : 24891066
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥97% (TLC)
• Forme: powder
• Couleur: white
• Solubilité: DMSO: soluble; ethanol: soluble
• Température de stockage: −20°C
• Chaîne SMILES: [H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
• InChI: 1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
• Clé InChI: FMYKJLXRRQTBOR-BZSNNMDCSA-N
• Informations sur le gène: human ... CAPN1(823) , CTSB(1508) , PSMA1(5682)

Description

Application

Calpain Inhibitor I have been used:

• as a component of protease inhibitor cocktail for gel shift analysis[1]
• for treating HeLa cell cultures[2]
• for inhibition of 26 S proteasome in 26 S proteasome inhibition assays[3]

Actions biochimiques/physiologiques

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis.[4] It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..[5]

Can initiate apoptosis in HL-60 cells[6] but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.[7] Inhibits cyclin B degradation and arrests the cell cycle at G₁/S and at meta-/anaphase.[8] Blocks induction of nitric oxide synthase by LPS in macrophages.[9]

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)