1.03668

D-mannitol

EMPROVE^® EXPERT, Ph. Eur., BP, JP, USP, E 421

• Synonyme(s) : D-Mannitol
• Formule empirique (notation de Hill) : C₆H₁₄O₆
• Numéro CAS: 69-65-8
• Poids moléculaire : 182.17
• Numéro MDL: MFCD00064287
• Code UNSPSC : 12352107
• Numéro E: E421
• Numéro de classement CE : 200-711-8

Propriétés

• Agence: BP; JP; Ph. Eur.; USP
• Niveau de qualité: 500
• Gamme de produits: EMPROVE^® EXPERT
• Forme: fine powder
• Taille des particules: 145-200 μm (d50)
• pH: 5-7 (20 °C, 100 g/L in H₂O)
• Pf: 164-169 °C
• Solubilité: 213 g/L
• Application(s): liquid formulation; pharmaceutical; solid formulation
• Température de stockage: 2-25°C
• Chaîne SMILES: OC(C(O)C(O)CO)C(O)CO
• InChI: 1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2
• Clé InChI: FBPFZTCFMRRESA-UHFFFAOYSA-N

Description

Description générale

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Parteck^® M DPI is a synthetic and versatile carrier option for your dry powder inhalation (DPI) formulation. Engineered from mannitol, Parteck^® M DPI particles are designed to improve the flow and release characteristics of active pharmaceutical ingredients (APIs) in drugs delivered via dry, inhaled powders.
As Emprove^® Expert product, Parteck^® M DPI is specified with low low microbial and endotoxin limits, making is especially suitable for high-risk applications.

Caractéristiques et avantages

• Particle distribution designed to improve flow and release characteristics in DPI application
• Low water content & hygroscopicity
• Synthesized from plant-based raw materials
• 3-year shelf life
• High API delivery to the lungs

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1