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367710

Sigma-Aldrich

Trichloroacetic anhydride

technical grade, 95%

Synonyme(s) :

(2,2,2-Trichloroacetyl) 2,2,2-trichloroacetate, Trichloroacetic acid anhydride

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About This Item

Formule linéaire :
(Cl3CCO)2O
Numéro CAS:
4124-31-6
Poids moléculaire :
308.76
Numéro Beilstein :
980355
Numéro CE :
223-925-3
Numéro MDL:
MFCD00000793
Code UNSPSC :
12352100
ID de substance PubChem :
24862827
Nomenclature NACRES :
NA.22

Qualité

technical grade

Pureté

95%

Forme

liquid

Indice de réfraction

n20/D 1.484 (lit.)

Point d'ébullition

139-141 °C/60 mmHg (lit.)

Densité

1.69 g/mL at 25 °C (lit.)

Chaîne SMILES 

ClC(Cl)(Cl)C(=O)OC(=O)C(Cl)(Cl)Cl

InChI

1S/C4Cl6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10

Clé InChI

MEFKFJOEVLUFAY-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Trichloroacetic anhydride is reported to be an efficient derivatization reagent, since it produces stable derivatives having both a higher mass fragmentation pattern and lesser volatility than derivatives of trifluoroacetic anhydride (TFAA) or heptafluorobutyric anhydride (HFBA). The interaction of thymidine 5′-phosphate with trichloroacetic anhydride in dimethylformamide and acetonitrile in the presence of tertiary amines hs been studied.

Application

Trichloroacetic anhydride may be used as derivatization reagent for the following studies:
  • Simultaneous analysis of amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in urine samples by solid-phase extraction, derivatization and gas chromatography/mass spectrometry.
  • Analysis of halogenated amphetamines in brain tissue from rats by gas chromatography with electron-capture detection (GC-ECD).
  • Quantitative determination of the metabolites of l-alpha-acetylmethadol (LAAM), such as noracetylmethadol, dinoracetylmethadol, methadol and normethadol by electron capture gas-liquid chromatography.

Pictogrammes

CorrosionExclamation mark
GHS05,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H314

Classification des risques

Acute Tox. 4 Oral - Skin Corr. 1A

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

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V S Bogachev et al.
Bioorganicheskaia khimiia, 29(1), 64-74 (2003-03-28)
The interaction of thymidine 5'-phosphate with trichloroacetic anhydride, trichloroacetyl chloride, and tribromoacetyl bromide was studied in dimethylformamide and acetonitrile in the presence of tertiary amines. The first two reactions gave the mixed anhydride of trichloroacetic and thymidylic acids (acyl phosphate)
R J Czarny et al.
Journal of analytical toxicology, 13(5), 257-262 (1989-09-01)
An analytical procedure for methamphetamine and amphetamine has been developed using 4-carbethoxyhexafluorobutyryl chloride. This derivatizing reagent has all the previously reported advantages of trichloroacetic anhydride (TCAA) in that it produces stable derivatives having both a higher mass fragmentation pattern and
M L Owen et al.
Journal of pharmacological methods, 25(2), 147-155 (1991-04-01)
p-Chloro-alpha-fluoromethylphenylethylamine (fluoro-p-chloroamphetamine) (FpCA) has been shown in acute studies to be a less potent depletor of the neurotransmitter amine 5-hydroxytryptamine (5-HT) in brain than is p-chloroamphetamine (pCA). Gas chromatographic assay procedures for FpCA and PCA have been developed in our
B K Gan et al.
Journal of forensic sciences, 36(5), 1331-1341 (1991-09-01)
A rapid and effective solid-phase extraction procedure using Bond Elute Certify bonded silica sorbent cartridges was adopted to extract amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) from urine samples. The extract was derivatized with trichloroacetic anhydride prior to gas chromatography/mass
D H Lau et al.
Journal of chromatography, 129, 329-338 (1976-12-22)
Six reagents-trichloroacetyl chloride, trichloroacetic anhydride, pentafluorobenzoyl chloride, heptafluorobutyryl chloride, heptafluorobutyric anhydride, and trifluoroacetic anhydride- were evaluated as potential derivatizing reagents for quantitating the metabolites of l-alpha-acetylmethadol (LAAM) -noracetylmethadol, dinoracetylmethadol, methadol, and normethadol-by electron capture gas-liquid chromatography. All of the reagents
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