Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

ZUSAMMENFASSUNG

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

298093

Sigma-Aldrich

Platin, gauze, 100 mesh, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinschwarz, black, powder, ≤20 μm, ≥99.95% trace metals basis

327492

Sigma-Aldrich

Platin, wire, diam. 1.0 mm, 99.9% trace metals basis

267201

Sigma-Aldrich

Platin, wire, diam. 0.5 mm, 99.99% trace metals basis

267244

Sigma-Aldrich

Platin, foil, thickness 0.025 mm, 99.9% trace metals basis

204013

Sigma-Aldrich

Platin, powder, 99.995% trace metals basis

349402

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, 99.9% trace metals basis

298107

Sigma-Aldrich

Platin, gauze, 52 mesh, 99.9% trace metals basis

267228

Sigma-Aldrich

Platin, wire, diam. 0.5 mm, 99.9% trace metals basis

685453

Sigma-Aldrich

Platin, nanopowder, <50 nm particle size (TEM)

520780

Sigma-Aldrich

Platinschwarz, fuel cell grade, ≥99.9% trace metals basis

349356

Sigma-Aldrich

Platin, foil, thickness 0.05 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platin, wire, diam. 2.0 mm, 99.9% trace metals basis

357367

Sigma-Aldrich

Platin, wire, diam. 0.10 mm, 99.99% trace metals basis

267171

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, 99.99% trace metals basis

GF49364264

Platin, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

771937

Sigma-Aldrich

Platin, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

520799

Sigma-Aldrich

Platinschwarz, low bulk density, ≥99.9% trace metals basis

GF98759200

Platin, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

349321

Sigma-Aldrich

Platin, foil, thickness 0.25 mm, 99.99% trace metals basis

267163

Sigma-Aldrich

Platin, wire, diam. 0.127 mm, 99.99% trace metals basis

349372

Sigma-Aldrich

Platin, foil, thickness 1.0 mm, 99.99% trace metals basis

GF80394914

Platin, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.99+%

GF60279576

Platin, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%

GF21250594

Platin, tube, 100mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%

204048

Sigma-Aldrich

Platin, powder (coarse), 99.99% trace metals basis

GF22473941

Platin, wire reel, 10m, diameter 0.025mm, hard, 99.9%

373265

Sigma-Aldrich

Platin, wire, diam. 0.25 mm, thermocouple grade

GF90182257

Platin, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%

GF02251730

Platin, rod, 200mm, diameter 1.0mm, 99.95%