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Platelet counts and liver enzymes after bariatric surgery.

Journal of obesity (2013-03-20)
Hans-Erik Johansson, Arvo Haenni, Björn Zethelius
ZUSAMMENFASSUNG

Obesity is characterized by liver steatosis, chronic inflammation, and increased liver enzymes, that is, gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for nonalcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are associated with inflammatory conditions and are a valuable biomarker of the degree of fibrosis in NAFLD. We investigated alterations in PC, GGT, and ALT after biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP). Ten morbidly obese patients (body mass index, BMI: 53.5 ± 3.8 kg/m(2)) who underwent BPD-DS were evaluated preoperatively (baseline) and 1 year (1st followup) and 3 years (2nd followup) after surgery and compared with 21 morbidly obese patients (BMI: 42.3 ± 5.2 kg/m(2)) who underwent RYGBP. Over the 3 years of followup, changes in BPD-DS and RYGBP patients (BPD-DS/RYGBP) were as follows: BMI (-44%/-24%), GGT (-63%/-52%), and ALT (-48%/-62%). PC decreased (-21%) statistically significantly only in BPD-DS patients. Morbidly obese patients treated by RYGBP or BPD-DS show sustained reductions in BMI, ALT, and GGT. The decrease in PC and liver enzymes after BPD-DS may reflect a more pronounced decrease of liver-fat-content-related inflammation and, as a result, a lowered secondary thrombocytosis.

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Produktbeschreibung

Sigma-Aldrich
Glutam-Brenztraubentransaminase aus Schweineherz, lyophilized powder, ≥75 units/mg protein
Sigma-Aldrich
γ-Glutamyltranspeptidase from equine kidney, Type VI, 5-12 units/mg solid
Sigma-Aldrich
Glutam-Brenztraubentransaminase aus Schweineherz, ammonium sulfate suspension, ≥75 units/mg protein
Sigma-Aldrich
γ-Glutamyltranspeptidase aus Schweineniere, Type IV, 2.0-6.0 units/mg solid
γ-Glutamyl-Transferase, ERM®, certified reference material