1096724

Carmustin

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 1,3-Bis-(2-chlorethyl)-1-nitroso-harnstoff, BCNU
• Empirische Formel (Hill-System): C₅H₉Cl₂N₃O₂
• CAS-Nummer: 154-93-8
• Molekulargewicht: 214.05
• MDL-Nummer: MFCD00057706
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329749246
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• API-Familie: carmustine
• Form: (Oily liquid to amorphous solid)
• Hersteller/Markenname: USP
• mp (Schmelzpunkt): 30 °C (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: −20°C
• SMILES String: ClCCNC(=O)N(CCCl)N=O
• InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
• InChIKey: DLGOEMSEDOSKAD-UHFFFAOYSA-N
• Angaben zum Gen: human ... GSR(2936)

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

• Enhancing glioblastoma treatment: Overexpression of Let-7a-3p in U87MG glioblastoma cells enhances chemosensitivity to Carmustine, promoting autophagy and suppressing cell survival, suggesting its role in improving outcomes in glioblastoma multiforme treatment using antineoplastic alkylating compounds (Bahojb Mahdavi et al., 2024).


• Pharmacogenomic profiling in renal cancer: Characterization of mitoribosomal small subunit genes in renal cell carcinoma reveals significant implications for Carmustine′s pharmacogenomic interaction, enhancing understanding of its mechanism in cancer therapy and providing a basis for personalized treatment approaches (Wei et al., 2024).

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H300,H350,H360
• P-Sätze: P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable