Z3003

Zardaverine

Name: Zardaverine
Brand: SIGMA
Price: 174 CHF

powder, ≥98% (HPLC)

Synonym(e):

6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

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5 MG

CHF 174.00

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₂H₁₀F₂N₂O₃

CAS-Nummer:

101975-10-4

Molekulargewicht:

268.22

UNSPSC Code:

12352202

PubChem Substance ID:

24278784

NACRES:

NA.77

MDL number:

MFCD00867059

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Unterstützung erhalten

Produktname

Zardaverine,

Quality Level

200

SMILES string

COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2

InChI

1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)

InChI key

HJMQDJPMQIHLPB-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

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Dieser Artikel	C7971	SRP0262	SRP0429
Sigma-Aldrich Z3003 Zardaverine	Sigma-Aldrich C7971 Cilostamide	Sigma-Aldrich SRP0262 PDE4A1A Active human	Sigma-Aldrich SRP0429 PDE4A10 active human
Gene Information human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638)	Gene Information human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638)	Gene Information human ... PDE4A(5141)	Gene Information human ... PDE4A(5141)
Quality Level 200	Quality Level 100	Quality Level -	Quality Level -

Application

Zardaverine has been used as a phosphodiesterase inhibitor:

to study its effects on human colonic epithelial cells[1]
to study its effects on junctional proteins in Sertoli cells[2]
to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells[3]

Biochem/physiol Actions

Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.[3]

Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.

R T Schermuly et al.

American journal of respiratory and critical care medicine, 160(5 Pt 1), 1500-1506 (1999-11-11)

Inhalation of aerosolized prostaglandin I(2) (PGI(2)) causes selective pulmonary vasodilation, but the effect rapidly levels off after termination of nebulization. In experimental pulmonary hypertension in intact rabbits, provoked by continuous infusion of the stable thromboxane mimetic U46619, the impact of

Bronchodilator and positive inotropic activity of pyridazine compound Zardaverine as a phosphodiesterase isozymes inhibitor

Asif M

Journal of Chemical and Pharmaceutical Sciences , 3(1), 31-34 null

Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol.

G Dent et al.

The Journal of pharmacology and experimental therapeutics, 271(3), 1167-1174 (1994-12-01)

The cyclic AMP phosphodiesterase (PDE) III/IV inhibitor, zardaverine, and the PDE IV-selective inhibitor, rolipram, both caused concentration-dependent inhibition of opsonized zymosan-stimulated superoxide anion generation by purified human peripheral blood eosinophils with approximate IC50 values of 30 and 40 microM, respectively.

Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.

K F Rabe et al.

The American journal of physiology, 264(5 Pt 1), L458-L464 (1993-05-01)

The effects of the nonselective phosphodiesterase (PDE)-inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE inhibitors SKF 94120 (type III), rolipram (type IV), zardaverine (type III/IV), and zaprinast (type V) on inherent tone in human airways were investigated. Substantial relaxation was achieved

Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma.

T Brunnée et al.

The European respiratory journal, 5(8), 982-985 (1992-09-01)

Zardaverine is a newly developed selective phosphodiesterase III and IV inhibitor. This study investigates the bronchodilatory properties of zardaverine, administered by inhalation. Twelve patients with reversible bronchial obstruction (increase in forced expiratory volume in one second (change FEV1 % predicted)

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Global Trade Item Number

SKU	GTIN
Z3003-5MG	04061832950099

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Zardaverine