T5443

Tyrphostin AG 825

≥92.5%

• Synonym(e): 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
• Empirische Formel (Hill-System): C₁₉H₁₅N₃O₃S₂
• CAS-Nummer: 149092-50-2
• Molekulargewicht: 397.47
• MDL-Nummer: MFCD01074971
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329826823
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥92.5%
• Form: powder
• Löslichkeit: DMSO: soluble; methanol: soluble
• Lagertemp.: −20°C
• SMILES String: COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
• InChI: 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
• InChIKey: KXDONFLNGBQLTN-WUXMJOGZSA-N

Beschreibung

Anwendung

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

Biochem./physiol. Wirkung

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Leistungsmerkmale und Vorteile

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Angaben zur Herstellung

Tyrphostin AG 825 is soluble in DMSO and methanol.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)