SRP6548

ApoJ/Clusterin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(e): AAG4, CLI, Clusterin Apolipoprotein J, KUB1, MGC24903, SGP-2, SGP2, TRPM2
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥90% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: 51.1 kDa (23-449 aa with a C-terminal His-tag.)
• Verpackung: pkg of 1 mg; pkg of 10 μg; pkg of 50 μg
• UniProt-Hinterlegungsnummer: P10909
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... CLU(1191)

Beschreibung

Allgemeine Beschreibung

Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

Physikalische Form

Lyophilized from 2 mg/mL solution of ApoJ in 25 mM Na2HPO4 and 100 mM NaCl (pH 7.5).

Rekonstituierung

Reconstitute in dH2O to a working concentration of 0.5 mg/mL and let the lyophilized pellet dissolve completely.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable