SRP4928

Lipocalin-2 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• Synonym(e): 25 kDa α-2-microglobulin-related subunit of MMP-9, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, p25
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥95% (HPLC); ≥95% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~20 kDa
• Verpackung: pkg of 50 μg
• Methode(n): activity assay: suitable
• Verunreinigungen: endotoxin, tested
• NCBI-Hinterlegungsnummer: P80188
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... LCN2(3934)

Beschreibung

Allgemeine Beschreibung

Research area: Cell signaling. The gene LCN2 (lipocalin 2) is mapped to human chromosome 9q34.[1] LCN2, a secreted glycoprotein, is an adipokine.[2][3] It is expressed by many cells, such as respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells, and cardiomyocytes. LCN2 belongs to the lipocalin family.[4] LCN2 consists of the lipid binding domain that binds to small hydrophobic molecules and the ligand binding cavity that binds to bacterial and mammalian proteins called siderophores.[5]

Anwendung

LCN2 (lipocalin 2)-human has been used in the cell proliferation assay.[6]It has also been used in conductometric immunoassay in renal carcinoma cells.[7]

Biochem./physiol. Wirkung

LCN2 (lipocalin 2) potentially connects obesity and its related adipose inflammation.[2][3] LCN2 has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis.[4] It is an early marker of acute kidney injury, cardiovascular diseases, lupus nephritis, and intestinal inflammation.[5] LCN2 is upregulated in humans with heart failure.[4] It can associate with MMP9 (matrix metalloproteinase-9) and controls its stability.[8][2] Changes in the expression of LCN2 are associated with many cancers, including breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder, and kidney cancers.[2]LCN2 acts as a pleiotropicmolecule and plays a role in several pathophysiological and physiologicalactivities including immune response, inflammation, metabolic homeostasis, andinfection.[5]

Physikalische Form

Lyophilized with no additives.

Rekonstituierung

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable