SRP4304

NGF-beta from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Synonym(e): Nerve Growth Factor β, Ngf, Ngfb
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: mouse
• Rekombinant: expressed in E. coli
• Assay: ≥98% (SDS-PAGE)
• Form: lyophilized
• Wirksamkeit: 0.2 ng/mL ED₅₀
• Mol-Gew.: ~13.4 kDa
• Verpackung: pkg of 20 μg
• Verunreinigungen: endotoxin, tested
• NCBI-Hinterlegungsnummer: P01139
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: mouse ... Ngf(18049)

Beschreibung

Allgemeine Beschreibung

Nerve growth factor-β (NGF-β) belongs to the neurotrophin family.[1] The active form of human NGF-β is a homodimer, non-glycosylated chain.[2]

Biochem./physiol. Wirkung

Nerve growth factor-β (NGF-β) is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells.[1] It brings pro-survival effects with the help of receptor tyrosine kinase TrkA.[3] NGF-β is associated with diabetic neuropathy and ischemic heart disease.[1] It is also involved in airway nerve system.[4] NGF-β is also responsible for the pain which is linked with osteoarthritis (OA).[5] It is involved in liver fibrosis, carcinogenesis, angiogenesis and cholangiocyte proliferation.[6]

Physikalische Form

Lyophilized without any additives.

Rekonstituierung

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL containing 1% HSA or BSA. The solution can be diluted into other aqueous buffers and stored at 4°C for 2-7 days or store at –20°C for future use.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable