SML4078

MitoBloCK-10

≥98% (HPLC)

• Synonym(e): 3-​Fluoro-​benzoic acid 2-​[(5-​nitro-​2-​thienyl)​methylene]​hydrazide, 3-Fluoro-N’- [(5-nitro-2-thienyl)methylene]benzohydrazide, MB-10, Mitochondrial import blockers of the Carla Koehler laboratory-10
• Empirische Formel (Hill-System): C₁₂H₈FN₃O₃S
• CAS-Nummer: 394694-98-5
• Molekulargewicht: 293.27
• MDL-Nummer: MFCD00813373
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C

Beschreibung

Biochem./physiol. Wirkung

Mitochondrial import blocker of substances requiring inner membrane translocon TIM23.
MitoBloCK-10 (MB-10) is mitochondrial import blocker of substances requiring inner membrane translocon TIM23 (TIM23) in yeast and mammalian mitochondria. It appears that MB-10 targets Tim44 of the PAM complex. MitoBloCK-10 does not alter respiraton. MB-10 inhibits cardiac development and induces apoptosis in Zebrafish embryos. It inhibits bladder cancer cell growth in vitro and in vivo.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable