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SML2146

Sigma-Aldrich

SR-18292 Maleate

≥98% (HPLC)

Synonym(e):

SR-18292 Maleate, 1-[(1,1-Dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-2-propanol maleate, SR 18292, SR 18292 maleate

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CHF 443.00

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5 MG
CHF 188.00
25 MG
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About This Item

Empirische Formel (Hill-System):
C23H30N2O2 · C4H4O4
CAS-Nummer:
2095432-55-4
Molekulargewicht:
482.57
UNSPSC-Code:
12352200
NACRES:
NA.77

CHF 188.00

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Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 2 mg/mL, clear

Lagertemp.

2-8°C

SMILES String

CC(C)(C)N(CC(O)COC1=CC=CC2=C1C=CN2)CC3=CC=C(C)C=C3.O=C(O)/C=C\C(O)=O

InChIKey

CMTOYDGVFTZNSM-BTJKTKAUSA-N

Anwendung

SR-18292 Maleate has been used as a peroxisome proliferator-activated receptor γ coactivator 1 α (PGC1α) inhibitor to study the protective effects of pioglitazone on demyelinated axons.[1]

Biochem./physiol. Wirkung

SR-18292 is a potent and specific inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α and suppression of gluconeogenic gene expression. SR-18292 reduces blood glucose and increases hepatic insulin sensitivity in mouse models of T2D.
inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α; anti-diabetic

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Die Dokumentenbibliothek aufrufen

Simon Licht-Mayer et al.
Acta neuropathologica, 140(2), 143-167 (2020-06-24)
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood. The abundance of mitochondria in demyelinated axons in MS raises
Kfir Sharabi et al.
Cell, 169(1), 148-160 (2017-03-25)
Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver
Rama Krishna Nimmakayala et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(19), 5415-5429 (2021-06-27)
Metabolic reprogramming and cancer stem cells drive the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). However, the metabolic and stemness programs of pancreatic precursor lesions (PPL), considered early PDAC development events, have not been thoroughly explored. Meta-analyses using gene expression profile
Prakash P Praharaj et al.
Autophagy, 20(6), 1359-1382 (2024-03-07)
Mitophagy involves the selective elimination of defective mitochondria during chemotherapeutic stress to maintain mitochondrial homeostasis and sustain cancer growth. Here, we showed that CLU (clusterin) is localized to mitochondria to induce mitophagy controlling mitochondrial damage in oral cancer cells. Moreover

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