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SML2118

Sigma-Aldrich

HA15

≥98% (HPLC)

Synonym(e):

N-[4-[3-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-acetamide

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About This Item

Empirische Formel (Hill-System):
C23H22N4O3S2
CAS-Nummer:
1609402-14-3
Molekulargewicht:
466.58
MDL-Nummer:
MFCD30377202
UNSPSC-Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 2 mg/mL, clear

Lagertemp.

2-8°C

SMILES String

CC(NC1=NC(C2=CC=CC(NS(C3=C(C=CC=C4N(C)C)C4=CC=C3)(=O)=O)=C2)=CS1)=O

Biochem./physiol. Wirkung

HA15 is a selective ligand of BiP/GRP78/HSPA5 chaperone that increases ER stress, leading to autophagic and apoptotic cell death in varies cancer cell lines including melanoma cells. HA15 inhibits inhibit the ATPase activity of BiP. HA15 inhibits tumor development in mice injected with A375 melanoma cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Analysenzertifikate (COA)

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Michaël Cerezo et al.
Autophagy, 13(1), 216-217 (2016-10-30)
Treatment of melanoma has significantly advanced over the last decade, with the development of targeted therapies against the MAPK pathway and immunotherapies to reactivate antitumor immunity. Unfortunately, currently more than 50% of patients are in treatment failure. Thus, identification of
Rossella Benedetti et al.
Biomedicines, 9(9) (2021-09-29)
Polyphenols have been shown to possess several beneficial properties, including properties involved in the prevention or treatment of cancer. Among these polyphenols, a leading role is played by dihydroxyphenylethanol (DPE), the most powerful antioxidant compound contained in the olive oil.
Michaël Cerezo et al.
Cancer cell, 29(6), 805-819 (2016-05-31)
We have discovered and developed a series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. Our

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