SML1991

PS432

≥98% (HPLC)

• Synonym(e): 2-[5-(4-chlorophenyl)-2-furanyl]-2,5-dihydro-4-hydroxy-1-(6-methyl-2-benzothiazolyl)-5-oxo-1H-pyrrole-3-carboxylic acid ethyl ester
• Empirische Formel (Hill-System): C₂₅H₁₉ClN₂O₅S
• CAS-Nummer: 2083630-26-4
• Molekulargewicht: 494.95
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• SMILES String: O=C1C(O)=C(C(OCC)=O)C(C2=CC=C(C3=CC=C(Cl)C=C3)O2)N1C4=NC(C=CC(C)=C5)=C5S4

Beschreibung

Biochem./physiol. Wirkung

Allosteric inhibitor of atypical PKC isoforms

PS432 is an allosteric inhibitor of Protein Kinase C (PKC) that targets regulatory site (PIF-pocket) present in the kinase domain. PS432 potently inhibits non-small cell lung cancer cells proliferation and tumor growth without side effects in a mouse xenograft model.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable