SML1801

CeMMEC13

≥98% (HPLC)

• Synonym(e): N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide
• Empirische Formel (Hill-System): C₁₉H₁₆N₂O₄
• CAS-Nummer: 1790895-25-8
• Molekulargewicht: 336.34
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329826074
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: CN(C1=C2C=CC=C1)C(C=C2C(NC3=CC=C4C(OCCO4)=C3)=O)=O

Beschreibung

Biochem./physiol. Wirkung

CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1 with an an IC₅₀ value of 2.1 μM and with minimal inhibition of BRD4, BRD9, CREBBP, or EP300. CeMMEC13 was found to synergize with BRD4 inhibitor (S)-JQ1 to arrest the proliferation of leukemia cell line THP1 and lung adenocarcinoma cell line H23.

CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable