SML1211

SMANT hydrochloride

≥98% (HPLC)

• Synonym(e): N-(4-Bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride
• Empirische Formel (Hill-System): C₁₆H₂₃BrN₂O · HCl
• CAS-Nummer: 1177600-74-6
• Molekulargewicht: 375.73
• MDL-Nummer: MFCD06620515
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329825721
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 1 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl
• InChI: 1S/C16H23BrN2O.ClH/c1-12-9-13(2)11-19(10-12)8-7-16(20)18-15-5-3-14(17)4-6-15;/h3-6,12-13H,7-11H2,1-2H3,(H,18,20);1H
• InChIKey: XQESCHFXROUCOQ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

SMANT is a Hedgehog pathway antagonist, a Smoothened antagonist that behaves similarly against normal cancer smoothened and the M2 mutant. In a study comparing activities among the currently known smoothened/Hedgehog antagonists, SMANT behaves differently, binding to another Smo site different to that bound by other compounds.

SMANT is a Hedgehog pathway antagonist; a Smoothened antagonist.

Sicherheitshinweise

• Piktogramme: GHS09
• H-Sätze: H411
• P-Sätze: P273 - P391 - P501
• Gefahreneinstufungen: Aquatic Chronic 2
• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable