SML0565

MK-0343

≥98% (HPLC)

• Synonym(e): 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine, MRK-409
• Empirische Formel (Hill-System): C₁₉H₁₇F₂N₇O
• CAS-Nummer: 233275-76-8
• Molekulargewicht: 397.38
• MDL-Nummer: MFCD22683821
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329825556
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: Cn1ncnc1COc2nn3c(nnc3cc2C4CCC4)-c5c(F)cccc5F
• InChI: 1S/C19H17F2N7O/c1-27-16(22-10-23-27)9-29-19-12(11-4-2-5-11)8-15-24-25-18(28(15)26-19)17-13(20)6-3-7-14(17)21/h3,6-8,10-11H,2,4-5,9H2,1H3
• InChIKey: GOIFCXRIFSYPFG-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

MK-0343 (MRK-409) is a partial agonist for GABAA receptors with comparable Ki values for α1, α2, α3 and α5 containing receptors (0.2 – 0.4 nM). The compound has the greatest agonist activity against α3 receptors, and is brain penatrant, and displays anxiolytic activity in rodent and primate models.

MK-0343 is a GABAA partial agonist.

Leistungsmerkmale und Vorteile

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable