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Merck

SML0550

Sigma-Aldrich

Nestorone

≥97% (HPLC)

Synonym(e):

17-(Acetyloxy)-16-methylene-19-norpregn-4-ene-3,20-dione, 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate, Elcometrine, Nestoron, ST-1435, ST1435

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10 MG
CHF 93.40
50 MG
CHF 355.00

CHF 93.40


Voraussichtliches Versanddatum23. April 2025


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10 MG
CHF 93.40
50 MG
CHF 355.00

About This Item

Empirische Formel (Hill-System):
C23H30O4
CAS-Nummer:
Molekulargewicht:
370.48
MDL-Nummer:
UNSPSC-Code:
51111800
PubChem Substanz-ID:
NACRES:
NA.77

CHF 93.40


Voraussichtliches Versanddatum23. April 2025


Bulk-Bestellung anfordern

Qualitätsniveau

Assay

≥97% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 5 mg/mL, clear

Lagertemp.

2-8°C

SMILES String

CC(=O)O[C@]1(C(C)=O)C(=C)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C

InChI

1S/C23H30O4/c1-13-11-21-20-7-5-16-12-17(26)6-8-18(16)19(20)9-10-22(21,4)23(13,14(2)24)27-15(3)25/h12,18-21H,1,5-11H2,2-4H3/t18-,19+,20+,21-,22-,23-/m0/s1

InChIKey

CKFBRGLGTWAVLG-GOMYTPFNSA-N

Angaben zum Gen

human ... PGR(5241)

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Dieser Artikel
SML1469H5270SML1468
Nestorone ≥97% (HPLC)

SML0550

Nestorone

Dienogest ≥98% (HPLC)

SML1468

Dienogest

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

-

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

-

color

white to beige

Biochem./physiol. Wirkung

Nestorone is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities.
Nestorone is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. Nestorone has been used as a female contraceptive, and recent studies inidicate that it may be useful as a male contraceptive as well. It has also been shown to have neurogenic and neuroprotective activity.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

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Marilia Oliveira-Ribeiro et al.
Contraception, 73(6), 634-640 (2006-05-30)
This descriptive study evaluated endometrial histology, microvascular density and caliber, and quantification of matrix metalloproteinase (MMP-3) expression in long-term users of the Nestorone (NES)-releasing implant who presented or not endometrial breakthrough bleeding (BTB). Endometrial biopsies were obtained from 32 healthy
Pramod Vishwanath Prasad et al.
Steroids, 75(3), 252-264 (2010-01-13)
A synthetic progestin Nestorone is being developed for female-contraception. This study was conducted to determine the distribution, metabolism, and excretion of tritium-labeled Nestorone ((3)H Nestorone) in adult female rats. Rats were injected subcutaneously (S.C.) with a single dose of 400
Ian S Fraser et al.
Contraception, 76(6), 432-438 (2007-12-07)
Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. Six healthy postmenopausal volunteers, not
Xiao-Dong Fu et al.
BMC cancer, 8, 166-166 (2008-06-11)
Limited information is available on the effects of progestins on breast cancer progression and metastasis. Cell migration and invasion are central for these processes, and require dynamic cytoskeletal and cell membrane rearrangements for cell motility to be enacted. We investigated
E Lenzi et al.
The Journal of steroid biochemistry and molecular biology, 116(1-2), 15-20 (2009-04-23)
The aim of the present study was to evaluate the potential action of Nestorone (alone or in combination with estradiol valerate) on the level of allopregnanolone and of the opioid beta-endorphin in selected brain areas. Wistar ovariectomized rats were given

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