SML0187

CJ-13610

≥98% (HPLC)

• Synonym(e): Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
• Empirische Formel (Hill-System): C₂₂H₂₃N₃O₂S
• CAS-Nummer: 179420-17-8
• Molekulargewicht: 393.50
• MDL-Nummer: MFCD00948114
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329825216
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to tan
• Löslichkeit: DMSO: ≥10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
• InChI: 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
• InChIKey: VPTONMHDLLMOOV-UHFFFAOYSA-N

Beschreibung

Anwendung

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

Biochem./physiol. Wirkung

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC₅₀ = 70 nM).

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.[1]

Potent 5-lipoxygenase inhibitor

Leistungsmerkmale und Vorteile

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable