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SBR00020

Sigma-Aldrich

Zearalenone Ready Made Solution

1 mg/mL in DMSO

Synonym(e):

(3S,11E)-3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-methyl-,1H-2-benzoxacyclotetradecin-1,7(8H)-dione, F-2 toxin

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About This Item

Empirische Formel (Hill-System):
C18H22O5
CAS-Nummer:
17924-92-4
Molekulargewicht:
318.36
MDL-Nummer:
MFCD00133085
UNSPSC-Code:
85151701
NACRES:
NA.28

Form

liquid

Konzentration

1 mg/mL in DMSO

Lagertemp.

−20°C

InChI

1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1

InChIKey

MBMQEIFVQACCCH-QBODLPLBSA-N

Biochem./physiol. Wirkung

Zearalenone, a fungal mycotoxin produced by Fusarium graminearum, binds estrogen receptor (ER) causing conformational alteration to the receptor. Zearalenone is a common contaminant in cereal grain used for animal and human food. It exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans. Furthermore, zearalenone was found to act as an immune-toxic compound, which can cause food consumption reduction in rats.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

188.6 °F - closed cup

Flammpunkt (°C)

87 °C - closed cup

Analysenzertifikate (COA)

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Aflatoxin B1 from Aspergillus flavus

Sigma-Aldrich

A6636

Aflatoxin B1

Isis M Hueza et al.
Toxins, 6(3), 1080-1095 (2014-03-19)
The aim of this study was to assess the toxic effects of zearalenone (ZEA) on the immune function. Ovariectomised rats were treated daily by gavage with 3.0 mg/kg of ZEA for 28 days. Body weight gain, food consumption, haemotological parameters
Hitomi Takemura et al.
The Journal of steroid biochemistry and molecular biology, 103(2), 170-177 (2006-11-14)
In the present study, we compared the estrogenic activity of zearalenone (ZEN) and zeranol (ZOL) by determining their relative receptor binding affinities for human ERalpha and ERbeta and also by determining their uterotropic activity in ovariectomized female mice. ZOL displayed
Karolina Kowalska et al.
Environmental toxicology and pharmacology, 48, 141-149 (2016-10-25)
Zearalenone (ZEA), a fungal mycotoxin, is present in a wide range of human foods. Many animal studies have found ZEA to possess a disruptive effect on the hormonal balance, mainly due to its similarity to naturally-occurring estrogens. With increasing consciousness

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