SAB4502150

Anti-ATP6V1H antibody produced in rabbit

affinity isolated antibody

• Synonym(e): V-ATPase 50/57 kDa subunits, V-ATPase subunit H, VMA13, Vacuolar proton pump subunit H, Vacuolar proton pump subunit SFD
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 55 kDa
• Speziesreaktivität: mouse, human
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:20000; immunohistochemistry: 1:50-1:100
• NCBI-Hinterlegungsnummer: Q9UI12
• UniProt-Hinterlegungsnummer: Q9UI12
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ATP6V1H(51606)

Beschreibung

Allgemeine Beschreibung

The gene ATP6V1H (ATPase H⁺ transporting V₁ subunit H) is mapped to human chromosome 8q11.2. It encodes a lysosomal protein with a molar mass of 50/57kDa. This protein forms the subunit of vacuolar ATPase (V-ATPase), a protein widely found in various eukaryotic endomembrane organelles. V-ATPase is a member of the rotary ATPase family, the members of which use rotary motor mechanisms for the transportation of ions across membranes. V-ATPase has two domains, V₀ and V₁ that function in transportation of proton and hydrolysis of ATP, respectively. The V₁ domain is composed of eight subunits, A-H.

Immunogen

The antiserum was produced against synthesized peptide derived from human ATP6V1H.

Immunogen Range: 341-390

Biochem./physiol. Wirkung

The gene ATP6V1H (ATPase H⁺ transporting V₁ subunit H) encodes the regulatory subunit H of the V₁ domain of V-ATPase. This multisubunit complex of V-ATPase functions in the acidification of intracellular compartments via the energy generated from ATP hydrolysis. Therefore, V-ATPase participates in receptor-mediated endocytosis, intracellular trafficking processes and degradation of proteins. Down-regulation of ATP6V1H gene in human pancreatic islets has been associated with type 2 diabetes. Its expression is negatively associated with HbA1c levels. It has a positive regulatory effect on glucose-stimulated insulin secretion.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable