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Merck

SAB4500889

Sigma-Aldrich

Anti-FGFR2 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

BEK, BFR-1, ECT1, FGFR-2, Fibroblast growth factor receptor 2 precursor

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 92 kDa

Speziesreaktivität

human, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... FGFR2(2263)

Allgemeine Beschreibung

Anti-FGFR2 Antibody detects endogenous levels of total FGFR2 protein.

Fibroblast growth factor receptor 2 (FGFR2), a membrane-spanning tyrosine kinase belongs to the fibroblast growth factor (FGF) family. It is expressed in epithelium, developing central nervous system and in bone rudiments. It is located on human chromosome 10q26.

Immunogen

The antiserum was produced against synthesized peptide derived from human FGFR2.

Immunogen Range: 471-520

Biochem./physiol. Wirkung

Fibroblast growth factor receptor 2 (FGFR2) mutations show poor clinical diagnosis in endometrioid endometrial cancer. The FGFR2 gene participates in directional epithelial-mesenchymal signaling in the endometrium. It is essential for placentation and limb induction.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
Xu X, et al.
Development, 125, 753-765 (1998)
The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations
Glaser RL, et al.
Nucleic Acids Research (2006)
FGFR2 mutations are associated with poor outcomes in endometrioid endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study.
Jeske YW
Gynecologic Oncology, 145, 366-366 (2017)
Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
Pollock PM, et al.
Oncogene, 26, 7158-7162 (2007)

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