SAB4500068
Anti-p27 KIP1 antibody produced in rabbit
affinity isolated antibody
Synonym(e):
CDKN1B, CDN1B, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, KIP1
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Alle Fotos(2)
About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Mol-Gew.
antigen 22 kDa
Speziesreaktivität
rat, mouse, human
Konzentration
~1 mg/mL
Methode(n)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... CDKN1B(1027)
Allgemeine Beschreibung
Anti-p27 KIP1 Antibody detects endogenous levels of total p27 KIP1 protein.
Cyclin-dependent kinase inhibitor 1B (CDKN1B or p27 KIP1) is a member of CDK inhibitor (CKI). The CDKN1B gene is mapped to human chromosome 12p13.1. The prime domains in CDKN1B include the nuclear export signal (NES) and the nuclear localization signal (NLS) and the CDK binding domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human p27 Kip1.
Immunogen Range: 1-50
Immunogen Range: 1-50
Anwendung
Anti-p27 KIP1 antibody produced in rabbit has been used in western blotting (1:500).
Biochem./physiol. Wirkung
Cyclin-dependent kinase inhibitor 1B (CDKN1B) negatively regulates cell cycle events by binding to cyclin-dependent kinase. It is a tumor suppressor gene correlated with the pathophysiology of tumors. Germline mutations in CDKN1B are implicated in multiple endocrine neoplasia (MEN) syndrome and MEN-like syndrome (MENX). It is a potent biomarker in acute myeloid leukemia.
Leistungsmerkmale und Vorteile
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physikalische Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
nwg
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Martina Kluth et al.
Oncotarget, 6(29), 27966-27979 (2015-08-22)
Deletion of 12p is a recurrent alteration in prostate cancer, but the prevalence and clinical consequences of this alteration have not been studied in detail. Dual labeling fluorescence in situ hybridization using probes for 12p13 (CDKN1B; p27) and centromere 12
Martina Cusan et al.
Frontiers in endocrinology, 9, 393-393 (2018-08-02)
The CDKN1B gene encodes for the p27Kip1 protein, firstly characterized as a cyclin dependent kinase (CDK)-inhibitor. Germline CDKN1B pathogenic variants have been described in hereditary tumors, such as multiple endocrine neoplasia (MEN)-like syndromes and familial prostate cancer. Despite its central
Gian Luca Rampioni Vinciguerra et al.
Cell division, 14, 2-2 (2019-04-13)
The p27kip1 protein, mainly known as a negative regulator of cell proliferation, has also been involved in the control of other cellular processes, including the regulation of cytoskeleton dynamics. Notably, these two functions involve distinct protein domains, residing in the
Ying Ding et al.
Molecular medicine (Cambridge, Mass.) (2015-04-01)
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R McKay
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