SAB4300675

Anti-Tyrosine Hydroxylase Antibody

rabbit polyclonal

• Synonym(e): Anti-tyrosine hydroxylase
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Produktbezeichnung: Anti-Th (Ab-31) antibody produced in rabbit, affinity isolated antibody
• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 55-60 kDa
• Speziesreaktivität: rat, mouse
• Konzentration: 1 mg/mL
• Methode(n): western blot: 1:500-1:1000
• Isotyp: IgG
• Immunogene Sequenz: (V-T-S-P-R)
• NCBI-Hinterlegungsnummer: NM_199292.2
• UniProt-Hinterlegungsnummer: P24529
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Th(21823)

Beschreibung

Allgemeine Beschreibung

Th (tyrosine hydroxylase) is a homotetramer that has regulatory, catalytic and tetramerization domains. The gene is located on chromosome llpl5.

The antibody detects endogenous levels of total Tyrosine Hydroxylase protein.

Immunogen

Peptide sequence around aa. 29-33 (V-T-S-P-R), according to the protein NP_954986.2

Biochem./physiol. Wirkung

Th (tyrosine hydroxylase) plays an important role in catecholamine synthesis as it helps in the hydroxylation of L-tyrosine to l-DOPA (l-3,4-dihydroxyphenylalanine). Th gene mutation results in tyrosine hydroxylase deficiency.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable