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SAB4300256

Sigma-Aldrich

Anti-phospho-NTRK2 (pTyr705) antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Anti-GP145-TrkB antibody produced in rabbit, Anti-TRKB antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 2 antibody produced in rabbit

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

~140 kDa

Speziesreaktivität

human, rat, mouse

Konzentration

1 mg/mL

Methode(n)

western blot: 1:500-1:1000

Isotyp

IgG

Immunogene Sequenz

(T-D-Y P-Y-R)

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pTyr705)

Angaben zum Gen

human ... NTRK2(4915)

Allgemeine Beschreibung

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on chromosome 9q21.32 .

Immunogen

Peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R), according to the protein NTRK2.

Anwendung

Anti-phospho-NTRK2 (pTyr705) antibody has been used in western blotting.

Biochem./physiol. Wirkung

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Zielbeschreibung

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder
Susick LL, et al.
Alcohol (2016)
Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model
Iyer R, et al.
Cancer Letters (2016)
Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma
Diamandis P, et al.
Diagnostic Pathology (2016)
A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects
Spalek K, et al.
Translational Psychiatry (2016)
Laura L Susick et al.
Alcohol (Fayetteville, N.Y.), 51, 25-35 (2016-03-20)
Brain-derived neurotrophic factor (BDNF) mediates neuron growth and is regulated by adenylyl cyclases (ACs). Mice lacking AC1/8 (DKO) have a basal reduction in the dendritic complexity of medium spiny neurons in the caudate putamen and demonstrate increased neurotoxicity in the

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