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Merck

SAB2702262

Sigma-Aldrich

Monoclonal Anti-COL11A2 antibody produced in mouse

clone GT473, affinity isolated antibody

Synonym(e):

DFNA13, DFNB53, FBCG2, HKE5

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About This Item

UNSPSC-Code:
12352203

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

GT473, monoclonal

Form

buffered aqueous solution

Speziesreaktivität

rat, human

Konzentration

1mg/mL

Methode(n)

indirect immunofluorescence: suitable
western blot: 1000-10000

Isotyp

IgG2a

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... COL11A2(1302)

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human COL11A2.

Anwendung

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem./physiol. Wirkung

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Three transcript variants encoding different isoforms have been identified for this gene. A pseudogene is located nearby on chromosome 6. [provided by RefSeq]

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Sonstige Hinweise

Purification: Affinity purified by Protein G

Physikalische Form

Phosphate-buffered saline, no preservative added.

Haftungsausschluss

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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