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SAB1307178

Sigma-Aldrich

ANTI-GSDMA(N-TERMINAL) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

GSDM, GSDM1, GSDMA, Gasdermin-1, Gasdermin-A

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400 μL
CHF 434.00

CHF 434.00

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400 μL
CHF 434.00

About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

CHF 434.00

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Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

49365 Da

Speziesreaktivität

mouse, human

Methode(n)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI-Hinterlegungsnummer

NP_835465.2

UniProt-Hinterlegungsnummer

Q96QA5

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GSDMA(284110)

Allgemeine Beschreibung

Gasdermin A (GSDMA) is located at 17q21.1 on the human chromosome. Its molecular weight is 49 kDa. GSDMA is localized in the pit cells of the gastric epithelium.

Biochem./physiol. Wirkung

Gasdermin A (GSDMA) plays a major role in regulating the tumor growth factor- β (TGF-β) and induces apoptosis. Mutation in this gene leads to gastric adenocarcinoma.

Physikalische Form

Supplied in PBS with 0.09% (W/V) sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SA100706AF

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Die Dokumentenbibliothek aufrufen

GSDMA (gasdermin A)
Saeki N and Sasaki H
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Yingwei Zhu et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 653-664 (2021-04-25)
Nonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH. Pyroptosis is mediated by inflammasome activation pathways including caspase-1-mediated canonical signaling pathway and caspase-11-mediated noncanonical signaling

Questions

1–2 of 2 Questions  

  1. Are the other bands in the representative blot distinguishing N-terminal domain (~36kDa), C-terminal domain (~28kDa), and a possible oligomer (~95kDa)?

    1 answer

    1. This antibody detects the N-terminal domain of Gasdermin A. The identities of the extra bands have not been determined, and it is unlikely that this antibody would cross-react with the C-terminal domain. Higher molecular weight bands could potentially correspond to an aggregate, but this has not been evaluated.

      Helpful?

  2. Hello, what is the Immunogen range of this antibody?

    1 answer

    1. This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA.
      According to the target sequence description and sequence provided on Uniprot, the sequence should be :
      PGSSPSDPTDTGNFGFKNMLDTRVEGDVD

      ???????https://www.uniprot.org/uniprotkb/Q96QA5/entry

      Helpful?

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