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P4623

Sigma-Aldrich

Anti-phospho-Interferon-α Receptor Type I (pSer535/pSer539) Subunit 1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-phospho-IFNα Receptor Type I (pSer535/pSer539) Subunit 1, Anti-phospho-IFNARI

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About This Item

MDL-Nummer:
MFCD07370443
UNSPSC-Code:
12352203
NACRES:
NA.46

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

rat, mouse, bovine, human

Methode(n)

western blot: 1:1,000 using using FLAG® immunoprecipitates from HEK 293 cells transfected with Mock, IFNAR1 wild type, or IFNAR1 S535A and S539A mutants

UniProt-Hinterlegungsnummer

P17181

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pSer535/pSer539)

Angaben zum Gen

human ... IFNAR1(3454)
mouse ... Ifnar1(15975)
rat ... Ifnar1(288264)

Verwandte Kategorien

Immunogen

synthetic phosphopeptide corresponding to the amino acid residues surrounding the human phospho-interferon-α receptor type I (pSer535/pSer539) subunit 1.

Biochem./physiol. Wirkung

Type I interferons (IFNα, IFNβ and IFNω) are pleotropic cytokines that mediate their cellular activities by binding to specific Type I IFN receptors. The functions of IFNα/ IFNα Receptor Type I axis include antiproliferative, antiviral and immunomodulatory activities.

Physikalische Form

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

Rechtliche Hinweise

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

P Domanski et al.
Cytokine & growth factor reviews, 7(2), 143-151 (1996-08-01)
The type-I interferon receptor is a multisubunit receptor of the cytokine receptor superfamily. The production of specific monoclonal antibodies against the receptor and the cloning of different receptor subunits have contributed to understanding the type-I interferon receptor structure and function.
L C Platanias et al.
The Journal of biological chemistry, 271(39), 23630-23633 (1996-09-27)
All Type I interferons (IFNalpha, IFNbeta, IFNomega) bind to the Type I IFN receptor (IFNR) and elicit a common set of signaling events, including activation of the Jak/Stat and IRS pathways. However, IFNbeta selectively induces the association of the alpha

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