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Merck

P4374

Sigma-Aldrich

Phthalocyanine tetrasulfonate hydrate

solid

Synonym(e):

29H,29H,31H-Phthalocyanine-C,C,C,C-tetrasulfonic acid, PcTS, Phthalocyanine tetrasulfonic acid, Tetrasulfophthalocyanine

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About This Item

Empirische Formel (Hill-System):
C32H18N8O12S4 · xH2O
CAS-Nummer:
Molekulargewicht:
834.79 (anhydrous basis)
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:

Form

solid

Qualitätsniveau

Lagerbedingungen

protect from light

Farbe

dark blue

Lagertemp.

2-8°C

SMILES String

[H]O[H].OS(=O)(=O)c1ccc2c3nc(nc4[nH]c(nc5nc(nc6[nH]c(n3)c7cc(ccc67)S(O)(=O)=O)c8cc(ccc58)S(O)(=O)=O)c9cc(ccc49)S(O)(=O)=O)c2c1

InChI

1S/C32H18N8O12S4.H2O/c41-53(42,43)13-1-5-17-21(9-13)29-33-25(17)37-30-22-10-14(54(44,45)46)2-6-18(22)27(34-30)39-32-24-12-16(56(50,51)52)4-8-20(24)28(36-32)40-31-23-11-15(55(47,48)49)3-7-19(23)26(35-31)38-29;/h1-12H,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H2,33,34,35,36,37,38,39,40);1H2

InChIKey

QNPPZKALMXYKPI-UHFFFAOYSA-N

Anwendung

Phthalocyanine tetrasulfonate hydrate has been used as a tau aggregation inhibitor (TAI) to study its effects on Tau secretion in neuroblastoma cells. It has also been used as an anionic phthalocyanine to study its effects on telomere G-quadruplex stabilization.

Biochem./physiol. Wirkung

Inhibitor of protein aggregation, including α-synuclein, and the formation of protease-resistant prion protein.

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Ciaran K McLoughlin et al.
Sensors (Basel, Switzerland), 20(18) (2020-09-16)
Fluorescein, and derivatives of fluorescein, are often used as fluorescent probes and sensors. In systems where pH is a variable, protonation/deprotonation of the molecule can influence the pertinent photophysics. Fluorination of the xanthene moiety can alter the molecule's pKa such
Maria Merezhko et al.
Cell reports, 25(8), 2027-2035 (2018-11-22)
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated misfolding of normal Tau in recipient cells.
Chang-yue Chen et al.
Journal of the American Chemical Society, 133(38), 15036-15044 (2011-08-19)
Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate
Takao Ohtomo et al.
Journal of analytical methods in chemistry, 2012, 520248-520248 (2012-05-09)
The chemiluminescence (CL) signal immediately appeared when a hydrogen peroxide solution was injected into an iron-phthalocyanine tetrasulfonic acid (Fe-PTS) aqueous solution. Moreover, the CL intensity of Fe-PTS decreased by adding l-tyrosine. Based on these results, the determination of trace amounts
Eui-Nam Lee et al.
Biochemistry, 43(12), 3704-3715 (2004-03-24)
Alpha-synuclein is a pathological component of Parkinson's disease by constituting the filamentous component of Lewy bodies. Phthalocyanine (Pc) effects on the amyloidosis of alpha-synuclein have been examined. The copper complex of phthalocyanine tetrasulfonate (PcTS-Cu(2+)) caused the self-oligomerization of alpha-synuclein while

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