O6881

Oxypurinol

≥98% (HPLC)

• Empirische Formel (Hill-System): C₅H₄N₄O₂
• CAS-Nummer: 2465-59-0
• Molekulargewicht: 152.11
• EG-Nummer: 219-570-9
• MDL-Nummer: MFCD00056934
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24898041
• NACRES: NA.51

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: 1 M NaOH: 49.00-51.00 mg/mL, clear to slightly hazy, colorless to yellow (heated NaOH)
• SMILES String: O=C1NC(=O)c2cn[nH]c2N1
• InChI: 1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
• InChIKey: HXNFUBHNUDHIGC-UHFFFAOYSA-N

Beschreibung

Anwendung

Oxypurinol has been used as a xanthine oxidase inhibitor, to evaluate its effects on hepatocellular carcinoma cell proliferation.[1] It has also been used as a xanthine inhibitor to elucidate its contribution in the induction of hpv16 late gene expression.[2]

Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.

Biochem./physiol. Wirkung

An allopurinol metabolite.

Oxypurinol has the ability to stimulate osteoblast differentiation and enhance the formation of bone. It is used to treat gout and hyperuricemia. Oxypurinol is considered as a strong antioxidant. It can prevent the actions of xanthine oxidase (XO) in osteoblasts.[3]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves