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Dokumente

M1568

Sigma-Aldrich

Mannose-Triflat

For PET imaging, ≥98% (TLC)

Synonym(e):

1,3,4,6-Tetra-O-acetyl-2-O-trifluormethansulfonyl-β-D-mannopyranose, β-D-Mannopyranose 1,3,4,6-tetra-O-acetat 2-O-Trifluormethansulfonat, Mannosetriflat, TATM

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About This Item

Empirische Formel (Hill-System):
C15H19F3O12S
CAS-Nummer:
92051-23-5
Molekulargewicht:
480.36
Beilstein:
4341413
MDL-Nummer:
MFCD00012353
UNSPSC-Code:
41116107
PubChem Substanz-ID:
24896669
NACRES:
NA.12

Qualitätsniveau

200

Assay

≥98% (TLC)

Methode(n)

PET imaging: suitable

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@@H](OS(=O)(=O)C(F)(F)F)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

InChI

1S/C15H19F3O12S/c1-6(19)25-5-10-11(26-7(2)20)12(27-8(3)21)13(14(29-10)28-9(4)22)30-31(23,24)15(16,17)18/h10-14H,5H2,1-4H3/t10-,11-,12+,13+,14-/m1/s1

InChIKey

OIBDVHSTOUGZTJ-PEBLQZBPSA-N

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Allgemeine Beschreibung

Mannose triflate is a glucose analogue.

Anwendung

Mannose triflate is a well-known precursor for 18F-FDG synthesis for PET applications. The binding of 18F to the mannose triflate has been carried out via SN2 nucleophilic substitution reaction. It is used in computational tomography, an imaging technique in early detection of cancer.

Sonstige Hinweise

This formulation of mannose triflate has reduced trace impurities that are known to cause lower synthetic yields.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Shane B Claggett et al.
EJNMMI research, 3(1), 53-53 (2013-07-17)
Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to
Ren Iwata et al.
Journal of labelled compounds & radiopharmaceuticals, 61(7), 540-549 (2018-03-10)
High specific activity is often a significant requirement for radiopharmaceuticals. To achieve that with fluorine-18 (18 F)-labeled probes, it is mandatory to start from no-carrier-added fluoride and to reduce to a minimum the amount of precursor in order to decrease
Padgett, H., et al.
Applied Radiation and Isotopes, 40, 433-433 (1989)
Salvador Castaneda Vega et al.
NeuroImage, 155, 245-256 (2017-05-06)
The clinical use of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) has proven to be a strong diagnostic tool in the field of neurology. The reliability of these methods to confirm clinical diagnoses has guided preclinical research to
Martin Thunemann et al.
Nature communications, 8(1), 444-444 (2017-09-07)
Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines
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