L4376

α-Lobelin -hydrochlorid

~95% (HPLC), powder

• Synonym(e): 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride, (−)-Lobeline hydrochloride
• Empirische Formel (Hill-System): C₂₂H₂₇NO₂ · HCl
• CAS-Nummer: 134-63-4
• Molekulargewicht: 373.92
• Beilstein: 3920196
• EG-Nummer: 205-150-2
• MDL-Nummer: MFCD00082455
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ~95% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: H₂O: 25 mg/mL
• SMILES String: Cl.CN1[C@@H](CCC[C@@H]1CC(=O)c2ccccc2)C[C@H](O)c3ccccc3
• Angaben zum Gen: human ... SLC18A2(6571)

Beschreibung

Biochem./physiol. Wirkung

Agonist at high-affinity neuronal nicotinic acetylcholine receptors; respiratory stimulant. Inhibits synaptosomal accumulation of dopamine by interaction with the tetrabenazine binding site of the vesicular monoamine transporter (VMAT2). Blocks amphetamine-induced dopamine release.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H331
• P-Sätze: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P403 + P233
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges