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Merck

I6260

Sigma-Aldrich

Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse

clone GG-7, ascites fluid

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.46

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

ascites fluid

Antikörper-Produkttyp

secondary antibodies

Klon

GG-7, monoclonal

Enthält

15 mM sodium azide

Methode(n)

indirect ELISA: 1:40,000

Isotyp

IgG1

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Allgemeine Beschreibung

Human IgGs are glycoprotein antibodies that contain two equivalent light chains and a pair of identical heavy chains. IgGs have four distinct isoforms, ranging from IgG1 to IgG4. These antibodies regulate immunological responses to allergy and pathogenic infections. IgGs have also been implicated in complement fixation and autoimmune disorders . Monoclonal Anti-Human IgG (Fc specific) antibody detects the Fc portion, but not the Fab portion, of human IgG. Additionally, the antibody does not react with IgA, IgM, and immunoglobulin light chains.
Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. An immunoglobulin has two heavy chains and two light chains connected by a disulfide bond. It is a glycoprotein and mainly helps in immune defense. IgG is usually found as a monomer. About 70 percent of the total immunoglobulin consists of IgG. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III.

Spezifität

Monoclonal Anti-Human IgG (Fc specific) antibody recognizes the fragment of crystallization (Fc) region of human immunoglobulin G (IgG) as determined by an enzyme-linked immunosorbent assay (ELISA).

Immunogen

Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads

Anwendung

Monoclonal Anti-Human IgG (Fc specific) antibody has been used:
  • to study the relationship between cell size, cell cycle and specific recombinant protein productivity
  • in the label-free homogeneous assay to identify inhibitors of a4b7 integrin-mediated cell adhesion to mucosal addressin cell adhesion molecule (MadCAM)
  • in enzyme-linked immunosorbent assay

Monoclonal Anti-Human IgG (Fc specific) antibody is suitable for use in indirect ELISA (1:5,000).

Biochem./physiol. Wirkung

IgG (immunoglobulin G) antibody provides protection against bacterial, fungal and viral infections. The Fc (fragment crystallization tail) region of the antibody is implicated in complement activation in which it elicits an immune response by binding to the Fc receptor on macrophages. The Fc region also serves as a site for rheumatoid factor (autoantibody directed to Fc) attachment and protein A binding. A certain population of lymphocytes also possess a "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of Human IgG.

Physikalische Form

This product is provided as ascites fluid with 0.1% sodium azide as a preservative.

Lagerung und Haltbarkeit

For continuous use, store at 0-5 ͦC. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Relationship between cell size, cell cycle and specific recombinant protein productivity
Lloyd D R, et al.
Cytotechnology, 34(1-2), 59-70 (2000)
A label-free approach to identify inhibitors of alpha4-beta7-mediated cell adhesion to MadCAM
Bova M P, et al.
Journal of Biomolecular Screening, 16(5), 536-544 (2011)
DEVELOPING AN ALTERNATE HOST FOR PRODUCTION OF BIOSIMILAR ANTI-EGFR MONOCLONAL ANTIBODY
Motiwala H M, et al.
International Journal of Pharmacy and Biological Sciences, 16(5), 536-544 (2012)
Role of antibodies in cancer targeting
Attarwala Husain
Journal of natural science, biology, and medicine, 1(1), 53-53 (2010)
Youmin Su et al.
International journal of molecular sciences, 24(22) (2023-11-25)
The interaction between integrin α4β7 and mucosal vascular addressin cell-adhesion molecule-1 (MAdCAM-1) facilitates the adhesion of circulating lymphocytes to the surface of high endothelial venules in inflammatory bowel diseases (IBDs). Lymphocyte adhesion is a multistep cascade involving the tethering, rolling

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