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I3901

Sigma-Aldrich

Interleukin-1α from rat

IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(e):

rIL-1α, IL-1α, Lymphocyte activating factor

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About This Item

MDL-Nummer:
MFCD01635091
UNSPSC-Code:
12352202
NACRES:
NA.77

Biologische Quelle

rat

Qualitätsniveau

100

Rekombinant

expressed in E. coli

Assay

≥97% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

1-10 pg/mL EC50

Qualität

endotoxin tested

Mol-Gew.

~18 kDa

Verpackung

pkg of 5 μg

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

≤0.1 EU/μg

UniProt-Hinterlegungsnummer

P16598

Lagertemp.

−20°C

Angaben zum Gen

rat ... Il1a(24493)

Biochem./physiol. Wirkung

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LA F), activates T cells and lymphocytes, which then proliferate and secrete Interleukin-2 (IL-2). The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Physikalische Form

Lyophilized from 0.2 μm filtered phosphate buffered saline containing 0.25 mg of bovine serum albumin.

Hinweis zur Analyse

The biological activity of recombinant rat IL-1α was measured by its ability to stimulate cell proliferation using a mouse helper T cell line, D10.G4.1.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Xuankang Wang et al.
Frontiers in neuroscience, 15, 768262-768262 (2021-11-20)
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) astrocytes and neuroprotective (A2) astrocytes. Our previous studies proved that photobiomodulation (PBM) can promote motor function recovery and improve
Xuankang Wang et al.
Journal of neuroinflammation, 18(1), 256-256 (2021-11-07)
Neurotoxic microglia and astrocytes begin to activate and participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage and affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation
T Nishida et al.
Journal of biochemistry, 105(3), 351-357 (1989-03-01)
A cDNA sequence coding for rat interleukin-1 alpha (IL-1 alpha) has been isolated from a cDNA library that was prepared with mRNA derived from LPS-stimulated rat peritoneal macrophages by using human IL-1 alpha cDNA as a probe. The rat cDNA
Sualyneth Galarza et al.
Advanced healthcare materials, 9(4), e1901419-e1901419 (2020-01-17)
Bioengineers have designed numerous instructive brain extracellular matrix (ECM) environments with tailored and tunable protein compositions and biomechanical properties in vitro to study astrocyte reactivity during trauma and inflammation. However, a major limitation of both protein-based and synthetic model microenvironments
Shuqi Jiang et al.
Journal of inflammation research, 14, 5919-5937 (2021-11-23)
Astrocyte A1/A2 phenotypes may play differential role in the pathogenesis of periventricular white matter (PWM) damage in septic postnatal rats. This study aimed to determine whether melatonin (MEL) would improve the axonal hypomyelination through shifting A1 astrocytes towards A2. One-day-old
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