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Merck

I148

Sigma-Aldrich

Imperatoxin A

>88%, lyophilized powder

Synonym(e):

Ip Txa

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About This Item

Empirische Formel (Hill-System):
C148H260N58O45S6
CAS-Nummer:
Molekulargewicht:
3764.40
MDL-Nummer:
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

Assay

>88%

Form

lyophilized powder

Lagertemp.

−20°C

Amino Acid Sequence

Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg

Biochem./physiol. Wirkung

Selective skeletal-type ryanodine sensitive intracellular Ca2+ channel activator found in the scorpion Pandinus
Selective skeletal-type ryanodine sensitive intracellular Ca2+ channel activator.

Leistungsmerkmale und Vorteile

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Analysenzertifikate (COA)

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H H Valdivia et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(24), 12185-12189 (1992-12-15)
We report the purification of two peptides, called "imperatoxin inhibitor" and "imperatoxin activator," from the venom of the scorpion Pandinus imperator targeted against ryanodine receptor Ca(2+)-release channels. Imperatoxin inhibitor has a M(r) of approximately 10,500, inhibits [3H]ryanodine binding to skeletal
F Z Zamudio et al.
FEBS letters, 405(3), 385-389 (1997-04-01)
We present the complete amino acid sequence of Imperatoxin A (IpTx(a)), a 33-amino-acid peptide from the venom of the scorpion P. imperator which activates Ca2+ release channels/ryanodine receptors (RyR) of sarcoplasmic reticulum (SR). The amino acid sequence of IpTx(a) shows
R el-Hayek et al.
The Journal of biological chemistry, 270(48), 28696-28704 (1995-12-01)
We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin A (IpTxa), a approximately 5-kDa peptide from the venom of the scorpion Pandinus imperator (Valdivia, H. H., Kirby, M. S., Lederer

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