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H2292

Sigma-Aldrich

Histone H3.1 human

Synonym(e):

Histone, Human

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100 μG
CHF 115.00

CHF 115.00

Voraussichtliches Versanddatum12. April 2025

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100 μG
CHF 115.00

About This Item

CAS-Nummer:
1523001-32-2
UNSPSC-Code:
12352202
NACRES:
NA.25

CHF 115.00

Voraussichtliches Versanddatum12. April 2025

Biologische Quelle

human

Qualitätsniveau

200

Rekombinant

expressed in E. coli

Form

liquid

Konzentration

1 mg/mL

Methode(n)

MALDI-TOF: suitable

UniProt-Hinterlegungsnummer

P68431

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... H3C1(8350)

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Allgemeine Beschreibung

Histone H3.1 is a histone H3 variant.[1] It differs from H3.2 with residue 96 being a cysteine instead of serine.[2] H3.1 is a replication-dependent histone and is a component of nucleosomes during the S-phase.[3]

Anwendung

Histone H3.1 human has been used in in vitro Schizosaccharomyces pombe Set7 histone methyltransferase assay for matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) studies.[4]

Biochem./physiol. Wirkung

Histone H3.1 human (H3.1) undergoes a majority of post-translational modification especially acetylation and demethylation in lysine 14 and 9 respectively.[1] During differentiation, the levels of H3.1 transcripts decrease as cell division slows down.[2] The incorporation of H3.1 into chromatin is mediated by a chaperone, chromatin assembly factor (CAF-1).[1] A transversion mutation in the H3.1 may be implicated in glioma.[3]

Physikalische Form

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319

Gefahreneinstufungen

Eye Irrit. 2

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000349247
0000341075
0000309409
0000349247
0000341075

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Sandra B Hake et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(17), 6428-6435 (2006-03-31)
In the history of science, provocative but, at times, controversial ideas have been put forward to explain basic problems that confront and intrigue the scientific community. These hypotheses, although often not correct in every detail, lead to increased discussion that
Gang Wu et al.
Nature genetics, 44(3), 251-253 (2012-01-31)
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found
Yunpeng Shen et al.
Structure (London, England : 1993), 27(4), 631-638 (2019-02-19)
Histone methylation by histone methyltransferases (HMTases) has a key role in transcriptional regulation. Discrepancies between the known HMTases and the histone lysine methylome suggest that HMTases remain to be identified. Here we report the discovery, characterization, and crystal structure of
Hideaki Tagami et al.
Cell, 116(1), 51-61 (2004-01-14)
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3

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