Direkt zum Inhalt
Merck

H1916

Sigma-Aldrich

Anti-HOXC9 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-HOX3B, Anti-Homeobox 3B, Anti-Homeobox C9, Anti-Hox-3.2 (MOUSE)

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~30 kDa

Speziesreaktivität

human

Konzentration

~1.0 mg/mL

Methode(n)

immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells over expressing human HOXC9
indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells, over expressing human HOXC9
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over expressing human HOXC9

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... HOXC8(3224)
mouse ... Hoxc8(15426)
rat ... Hoxc9(368178)

Allgemeine Beschreibung

Homeobox C9 (HOXC9) gene is a member of the conserved homeobox family and is located on the human chromosome at 12q13.13. This gene encodes for the HOXC9 transcription factor/protein.

Spezifität

Anti-HOXC9 (C-terminal) recognizes human HOXC9 (also known as Hox-3B).

Anwendung

Anti-HOXC9 (C-terminal) antibody produced in rabbit may be used in
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem./physiol. Wirkung

Homeobox C9 (HOXC9) transcription factor/ protein is involved in morphogenesis. Loss of this gene is associated with a hypermethylated state of its promoter in non-small cell lung cancer and breast cancer. HOXC9 protein produces neuronal differentiation and growth arrest in neuroblastoma cells and acts as a biomarker in neuroblastoma patients. HOXC9 gene expression is upregulated by retinoic acid. The HOXC9 gene expression is associated with astrocytomas malignancy and cervical cancer.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Lagerung und Haltbarkeit

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Haftungsausschluss

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

R López et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 16(3), 1289-1296 (2006-06-29)
The HOX genes are a family of transcription factors that bind to specific sequences of DNA in target genes regulating their expression. The role of HOX genes in adult cell differentiation is still obscure, but growing evidence suggests that they
Xudong Peng et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(4), 1659-1676 (2018-09-12)
Previous studies demonstrated that HOXC9 acts as an oncogene in several tumors. The aim of this study was to explore whether HOXC9 promotes gastric cancer (GC) progression and elucidate the underlying molecular mechanisms. HOXC9 expression in GC tissues and adjacent
Oswaldo K Okamoto et al.
Biochimica et biophysica acta, 1769(7-8), 437-442 (2007-06-26)
Comparative analysis of cancer stem cells with their neoplastic and non-neoplastic counterparts should help better understand the underlying molecular events leading to transformation and tumor dissemination. Here, we report a molecular signature comprised by genes with exclusive aberrant expression in
Ling Mao et al.
Cancer research, 71(12), 4314-4324 (2011-04-22)
Differentiation status in neuroblastoma strongly affects clinical outcomes and inducing differentiation is a treatment strategy in this disease. However, the molecular mechanisms that control neuroblastoma differentiation are not well understood. Here, we show that high-level HOXC9 expression is associated with
Lei Lv et al.
Cancer letters, 357(1), 105-113 (2014-12-03)
Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2.

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.