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GW22778

Sigma-Aldrich

Anti-GSK3a antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

chicken

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

rat, mouse, human

Hersteller/Markenname

Genway 15-288-22778

Methode(n)

indirect ELISA: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NP_063937.1

UniProt-Hinterlegungsnummer

P49840

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GSK3A(2931)

Immunogen

Immunogen Sequence: GI # 11995474, sequence 89-100
Synthetic peptide sequence of glycogen synthase kinase 3α.

Anwendung

Anti-GSK3α antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Glycogen synthase kinase-3α is an enzyme encoded by the GSK3A gene in humans and is located on chromosome 19q13.2. It is a serine-threonine kinase that exists as two isoforms, α and β. GSK-3α is widely expressed throughout the follicles and plays a role in cancer development such as acute myeloid leukemia (AML). It is an important component of the therapeutic actions of drugs used to treat mood disorders and can be a potential target for developing new therapeutic interventions.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Xiaohua Li et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(11), 2143-2154 (2010-07-30)
Little is known regarding the mechanisms underlying the complex etiology of mood disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 discovery that lithium inhibits glycogen synthase kinase-3 (GSK3) raised the possibility that impaired inhibition of GSK3
Koichi Yamauchi et al.
Archives of dermatological research, 302(4), 263-270 (2009-08-26)
Beta-catenin is involved in the hair follicle morphogenesis and stem cell differentiation, and inhibition of glycogen synthase kinase-3 (GSK-3) increases beta-catenin concentration in the cytoplasm. To examine the effects of GSK-3 inhibition on the hair follicle epithelium, we first examined
P C Shaw et al.
Genome, 41(5), 720-727 (1998-11-11)
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase that exists as two isoforms, alpha and beta, encoded by separate genes. Phosphorylation targets include a variety of cytoplasmic and nuclear proteins. Recent studies found that neurofilaments, amyloid precursor protein, and tau
Versha Banerji et al.
The Journal of clinical investigation, 122(3), 935-947 (2012-02-14)
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long-term survival of patients with AML has changed little over the past decade, necessitating the identification and validation of new AML targets. Integration of genomic approaches

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