D8696

DMH4

>99.0% (HPLC)

• Empirische Formel (Hill-System): C₂₄H₂₄ N₄O₂
• CAS-Nummer: 515880-75-8
• Molekulargewicht: 400.47
• MDL-Nummer: MFCD18452839
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798880
• NACRES: NA.77

Eigenschaften

• Assay: >99.0% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: off-white to brown
• Löslichkeit: DMSO: 20 mg/mL
• Ersteller: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Lagertemp.: 2-8°C
• SMILES String: C1CN(CCO1)CCOc2ccc(cc2)-c3cnc4c(cnn4c3)-c5ccccc5
• InChI: 1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
• InChIKey: SKZQZGSPYYHTQG-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable