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D7412

(±)-2,5-Dimethoxy-4-bromamphetamin -hydrobromid

Name: (±)-2,5-Dimethoxy-4-bromamphetamin -hydrobromid
Brand: SIGMA

Synonym(e):

(±)-DOB -hydrobromid

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About This Item

Empirische Formel (Hill-System):

C₁₁H₁₆BrNO₂ · HBr

CAS-Nummer:

53581-53-6

Molekulargewicht:

355.07

MDL-Nummer:

MFCD00069251

UNSPSC-Code:

12352116

PubChem Substanz-ID:

24894134

NACRES:

NA.77

Arzneimittelkontrolle

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

forensics and toxicology
veterinary

SMILES String

Br[H].COc1cc(CC(C)N)c(OC)cc1Br

InChIKey

KOUBEZAODVTFTG-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Halluzinogen; 5-HT₂ Serotoninrezeptor Agonist.

Piktogramme

GHS06

Signalwort

Danger

H-Sätze

H302,H310 + H330

P-Sätze

P260 - P262 - P280 - P301 + P312 - P302 + P352 + P310 - P304 + P340 + P310

Gefahreneinstufungen

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 4 Oral

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

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Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [3H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([3H]DOB), a 5-HT2 agonist radioligand.

M Titeler et al.

Biochemical pharmacology, 36(19), 3265-3271 (1987-10-01)

The affinities of putative serotonin receptor agonists and antagonists for 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT2 receptors were assayed using radioligand binding assays. The 5-HT1 sites were labeled with the agonist radioligands [3H]-8-hydroxy-2-(di-n-propylamino)-tetralin [3H]-8-OH-DPAT, [3H]-5-HT, and [3H]mesulergine. The 5-HT2 receptor was

Potent agonist activity of DOB at 5-HT2 receptors in guinea pig trachea.

W A Heller et al.

European journal of pharmacology, 138(1), 115-117 (1987-06-12)

DOB, 4-bromo-2,5-dimethyloxyamphetamine, a potent hallucinogen, displays high affinity for the 5-HT2 receptor in binding assays. Since 5-HT contractile responses in guinea pig trachea are mediated by 5-HT2 receptors, we assessed the activity of DOB and related analogs in this preparation.

Nonfatal and fatal DOB (2,5-dimethoxy-4-bromoamphetamine) overdose.

Marie Balíková

Forensic science international, 153(1), 85-91 (2005-06-28)

2,5-Dimethoxy-4-bromoamphetamine (DOB) is a strongly acting hallucinogen with an estimated effective dose of 2 mg for an 80 kg man. The case of two men who ingested a new "hallucinogen LSD-like" designer drug is reported here. They experienced intense hallucinations

Study on metabolites of 2,5-dimethoxy-4-bromamphetamine (DOB) in human urine using gas chromatography-mass spectrometry.

Katerina Beránková et al.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 149(2), 465-468 (2006-04-08)

The study of the biotransformation of a new synthetic drug 2,5-dimethoxy-4-bromamphetamine (DOB) and identification of its metabolites in urine of a poisoned person is described using gas chromatography mass spectrometry (GC-MS) with various ways of derivatization. It has been confirmed

'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.

Danielle M Schultz et al.

Bioorganic & medicinal chemistry, 16(11), 6242-6251 (2008-05-10)

Phenylalkylamines that possess conformationally rigidified furanyl moieties in place of alkoxy arene ring substituents have been shown previously to possess the highest affinities and agonist functional potencies at the serotonin 5-HT(2A) receptor among this chemical class. Further, affinity declines when

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