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C8759

Sigma-Aldrich

Carisoprodol

Synonym(e):

2-Methyl-2-propyl-1,3-propandiol-carbamat-isopropylcarbamat

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About This Item

Empirische Formel (Hill-System):
C12H24N2O4
CAS-Nummer:
78-44-4
Molekulargewicht:
260.33
EG-Nummer:
201-118-7
MDL-Nummer:
MFCD00057661
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278083

Arzneimittelkontrolle

USDEA Schedule IV

Löslichkeit

ethanol: soluble

Ersteller

Schering Plough

Lagertemp.

2-8°C

SMILES String

CCCC(C)(COC(N)=O)COC(=O)NC(C)C

InChI

1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16)

InChIKey

OFZCIYFFPZCNJE-UHFFFAOYSA-N

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Allgemeine Beschreibung

Carisoprodol (N-isopropyl-2-methyl-2-propyl-l,3-propanediol dicarbamate) is a dicarbamate that is structurally similar to mephenesin and meprobamate. It functions as a skeletal muscle relaxant and has analgesic properties. Although it does not have an effect on behavior, it inhibits reticular formation. The area associated with pain perception in the CNS is affected by carisoprodol for its analgesic activity.
Carisoprodol is actively metabolized to meprobamate, a depressant of the CNS having sedative hypnotic.

Anwendung

Carisoprodol has been used as a standard for quantitative determination of carisoprodol in tablets using high-performance thin-layer chromatography. It has also been used to study the effect of pharmacological agents on the muscles of dystrophin-deficient mdx5Cv mice.

Biochem./physiol. Wirkung

Metabolite of meprobamate that is a skeletal muscle relaxant, reduces muscle spasm by depression of brainstem neurons.

Leistungsmerkmale und Vorteile

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Michael B Gatch et al.
Drug and alcohol dependence, 123(1-3), 29-34 (2011-11-08)
Carisoprodol is a muscle relaxant that acts at the GABA(A) receptor. Concerns about the abuse liability of carisoprodol are increasing, but evidence that carisoprodol produces tolerance and a significant withdrawal syndrome has yet to be established. The purpose of the
Analysis of carisoprodol tablets by HPTLC with visible absorbance densitometry.
Fisher, J., and J. Sherma
Acta Chromatographica , 96-101 (2001)
James P Zacny et al.
Pharmacology, biochemistry, and behavior, 100(1), 138-143 (2011-09-03)
Carisoprodol is a centrally acting drug used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. There is evidence from different sources that this oral muscle relaxant is abused and that it is associated with impairment leading
R A Littrell et al.
Southern medical journal, 86(7), 753-756 (1993-07-01)
Carisoprodol (Soma, others) is a commonly prescribed, noncontrolled, skeletal muscle relaxant whose active metabolite is meprobamate. Patients for whom carisoprodol is prescribed are at risk for meprobamate dependence; several such cases have been reported. Toxicity and withdrawal associated with the
A Barnett et al.
European journal of pharmacology, 30(1), 23-28 (1975-01-01)
Some narcotic drugs have been reported to produce increases in muscle tone in rats. In our laboratory we have found that etonitazine produces a 'lead-pipe' rigidity of the trunk and limb musculature. The reported studies were conducted to characterize etonitazine-induced
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