C5490

C75

≥98% (HPLC), powder

• Synonym(e): 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
• Empirische Formel (Hill-System): C₁₄H₂₂O₄
• CAS-Nummer: 218137-86-1
• Molekulargewicht: 254.32
• MDL-Nummer: MFCD03426157
• UNSPSC-Code: 41121801
• PubChem Substanz-ID: 24892789
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
• InChI: 1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
• InChIKey: VCWLZDVWHQVAJU-UHFFFAOYSA-N

Beschreibung

Anwendung

C75 has been used:

• as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin[1]
• as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)[2]
• as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide[3]

Biochem./physiol. Wirkung

C75 helps to increase the cancer‐killing capability of ionizing radiation.[4]

C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)