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C5151

Sigma-Aldrich

3-Karbamoyl-PROXYL

Synonym(e):

3-Carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinoxy, 3-Carbamoyl-2,2,5,5-tetramethylpyrrolidin-1-yloxy, freies Radikal

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About This Item

Empirische Formel (Hill-System):
C9H17N2O2
CAS-Nummer:
4399-80-8
Molekulargewicht:
185.24
EG-Nummer:
224-533-5
MDL-Nummer:
MFCD00003168
UNSPSC-Code:
12352000
PubChem Substanz-ID:
24892761
NACRES:
NA.22

Form

powder

mp (Schmelzpunkt)

173-175 °C (lit.)

Lagertemp.

2-8°C

SMILES String

CC1(C)CC(C(N)=O)C(C)(C)N1[O]

InChI

1S/C9H17N2O2/c1-8(2)5-6(7(10)12)9(3,4)11(8)13/h6H,5H2,1-4H3,(H2,10,12)

InChIKey

XNNPAWRINYCIHL-UHFFFAOYSA-N

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Anwendung

A spin label useful for non-invasive detection of free radicals in vivo by electron spin resonance imaging.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

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Sigma-Aldrich

176141

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Sigma-Aldrich

214000

TEMPO

Ken-Ichiro Matsumoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(8), 2455-2462 (2006-04-28)
There is considerable research directed toward the identification and development of functional contrast agents for medical imaging that superimpose tissue biochemical/molecular information with anatomical structures. Nitroxide radicals were identified as in vivo radioprotectors. Being paramagnetic, they can provide image contrast
Guohan Hu et al.
Journal of neurosurgery, 98(2), 393-396 (2003-02-21)
Nitroxides mimic superoxide dismutase (SOD) biochemically and may prevent free radical oxidative injury in settings in which endogenous SOD is overwhelmed. The authors have previously shown the efficacy of a nitroxide, Tempol, in reducing stroke infarct size. Of the nitroxides
Tomiko Mikuni et al.
Cancer research, 64(18), 6495-6502 (2004-09-18)
Electron paramagnetic resonance imaging (EPRI) enables noninvasive spatial mapping of free radical metabolism and has recently been shown to provide in vivo physiologic information regarding alterations in the redox state of tumors and neoplastic tissues. With the use of nitroxide
Th Herrling et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 63(4), 840-845 (2006-03-18)
Free radicals/reactive oxygen species (ROS) generated in skin by UV irradiation were measured by electron spin resonance (ESR). To increase the sensitivity of measurement the short life free radicals/ROS were scavenged and accumulated by using the nitroxyl probe 3-carboxy-2,2,5,5-tetrametylpyrrolidine-1-oxyl (PCA).
T Herrling et al.
Free radical biology & medicine, 35(1), 59-67 (2003-06-27)
Reactive free radicals and reactive oxygen species (ROS) induced by ultraviolet irradiation in human skin are strongly involved in the occurrence of skin damages like aging and cancer. In the present work an ex vivo method for the detection of
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