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C4616

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Anti-Calcium Channel CaV3.3 (α1I) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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About This Item

MDL-Nummer:
MFCD06798429
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

lyophilized powder

Speziesreaktivität

rat

Methode(n)

western blot: 1:200 using rat brain membranes

UniProt-Hinterlegungsnummer

Q9Z0Y8

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CACNA1I(8911)
rat ... Cacna1i(56827)

Allgemeine Beschreibung

Calcium channel CaV3.3 (α1I) is a low-voltage-activated T-type calcium channel. CaV3.3 (α1I) transcripts are detected in central nervous system as well as thyroid and adrenal glands.

Immunogen

peptide corresponding to amino acid residues 1053-1067 of rat CaV3.3. Homology with other species: human is 14/15 residues identical.

Anwendung

Anti-Calcium Channel CaV3.3 (a1I) antibody produced in rabbit is suitable for western blot at a dilution of 1:200 using rat brain membranes.

Biochem./physiol. Wirkung

Calcium channel CaV3.3 (α1I) is involved in neuronal excitability and is particularly recruited during the depolarizing after-potential. It is responsible for generating sustained electrical activity. Sperm specific proteins CatSper1 and CatSper2 interact with Cav3.3 and suppress Cav3.3-evoked T-type calcium channel activity.

Physikalische Form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Edward Perez-Reyes
Physiological reviews, 83(1), 117-161 (2002-12-31)
T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because they can be activated by small depolarizations of the plasma membrane. In many neurons Ca2+ influx through LVA channels triggers low-threshold spikes, which in turn triggers a burst of action
Jean Chemin et al.
The Journal of physiology, 540(Pt 1), 3-14 (2002-04-03)
In several types of neurons, firing is an intrinsic property produced by specific classes of ion channels. Low-voltage-activated T-type calcium channels (T-channels), which activate with small membrane depolarizations, can generate burst firing and pacemaker activity. Here we have investigated the
Di Zhang et al.
The Journal of biological chemistry, 281(31), 22332-22341 (2006-06-03)
Sperm-specific CatSper1 and CatSper2 proteins are critical to sperm-hyperactivated motility and male fertility. Although architecturally resembling voltage-gated ion channels, neither CatSper1 nor CatSper2 alone forms functional ion channels in heterologous expression systems, which may be related to the absence of
Multiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses.
Zhang, et al.
The Journal of Neuroscience, 42, 6487-6505 (2023)

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