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A5486

Sigma-Aldrich

Azoxymethan

13.4 M, ≥98%

Synonym(e):

AOM

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25 MG
CHF 470.00
100 MG
CHF 1’530.00

CHF 470.00

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25 MG
CHF 470.00
100 MG
CHF 1’530.00

About This Item

Lineare Formel:
CH3N=N(→O)CH3
CAS-Nummer:
25843-45-2
Molekulargewicht:
74.08
MDL-Nummer:
MFCD00126912
UNSPSC-Code:
12352124
PubChem Substanz-ID:
329770827
NACRES:
NA.25

CHF 470.00

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Assay

≥98%

Form

liquid

Zusammensetzung

methylene chloride, ≤1%

Lagerbedingungen

(Keep container tightly closed in a dry and well-ventilated place.)

Konzentration

13.4 M

Farbe

colorless

bp

97-99 °C (lit.)

Dichte

0.991 g/mL at 25 °C (lit.)

Anwendung(en)

genomic analysis

Lagertemp.

−20°C

SMILES String

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChIKey

DGAKHGXRMXWHBX-ONEGZZNKSA-N

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Allgemeine Beschreibung

Azoxymethan (AOM) ist eine hochwirksame Laborchemikalie zur Untersuchung der Entstehung, Progression und Prävention von Krebs, insbesondere im Kolon. Es wirkt sowohl als Karzinogen, das die Tumorbildung auslöst, als auch als Genmutationswirkstoff, der spezifische Veränderungen der DNA verursacht.

Anwendung

Azoxymethan (AOM) ist ein Genmutationsmittel und kann zusammen mit Natriumdextransulfat (DSS) zur Erstellung von Krebsmodellen in Labortieren, die zur Untersuchung von Mechanismen der Krebsentwicklung und chemischen Vorbeugung dienen, verwendet werden.

Biochem./physiol. Wirkung

Karzinogen, das O6-Methylguanin-Addukte in der DNA induziert, was zu G→A-Übergängen führt. Induziert Tumorgenese im Darm von Labortieren und wird zur Untersuchung des Mechanismus der Krebsprogredienz und Chemoprävention verwendet.

Leistungsmerkmale und Vorteile

Vielseitig und anpassbar an eine Vielzahl von Labor- und Forschungsanwendungen

Sonstige Hinweise

Es ist äußerst wichtig, beim experimentellen Verfahren die genaue Azoxymethandosierung zu bestimmen, um einem frühzeitigen Tod der Labortiere vorzubeugen.
Füllen Sie bitte dieses Formular aus, um weitere Informationen zu unserem Sortiment an Biochemikalien zu erhalten.

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Timestrip Plus™ -20 °C

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 3

Flammpunkt (°F)

75.2 °F

Flammpunkt (°C)

24 °C

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000431531
0000431531
0000346490
0000346492
0000335812

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Die Dokumentenbibliothek aufrufen

Eva Pastille et al.
PLoS pathogens, 13(9), e1006649-e1006649 (2017-09-25)
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host's immune response by releasing immunomodulatory molecules
Sonia Leon-Cabrera et al.
Cancers, 10(9) (2018-09-22)
Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor⁻stroma interactions, and
Carlotta Tacconi et al.
Cancer research, 79(16), 4196-4210 (2019-06-27)
Colorectal cancer is a major cause of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LV) and tumor-associated macrophages (TAM). The VEGFC/VEGFR3 pathway is regarded as the principal inducer of lymphangiogenesis and it contributes
Shiyan Wang et al.
Cancer research, 79(16), 4086-4098 (2019-06-27)
Tripartite motif (TRIM) family proteins participate in a variety of important cellular processes, including apoptosis, cell-cycle arrest, DNA repair, and senescence. In this study, we demonstrated that a novel TRIM family member, TRIM67, was commonly silenced in colorectal cancer and
Qifan Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4779-4782 (2014-10-17)
Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense
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Questions

1–10 of 11 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the solubility of product A5486 (Azoxymethane, CAS number 25843-45-2)?

    1 answer

    1. The solubility of Azoxymethane (CAS 25843-45-2) is as follows:

      • Water solubility: approximately 100mg/mL
      • DMSO solubility: approximately 100mg/mL
      • Ethanol (95%) solubility: approximately 100mg/mL
      • Acetone solubility: approximately 100mg/mL

      Helpful?

  4. Could I know the concentration (mg/ml) and volume of Azoxymethane 13.4M in A5486-100MG?

    1 answer

    1. This product is considered to be a pure/neat chemical (not in solution), with a purity specification of at least 98%. The g/mL would be the density, of 0.991 g/mL. The volume of 100 mg is going to be approximately 100.9 microliters, but products are often over-filled by a few percent, so it would be recommended to still weigh the material during or prior to use.

      Helpful?

  5. Is Axozymethane volatile?

    1 answer

    1. Yes, this compound is considered to be a volatile substance. Please review the entire Safety Data Sheet before handling it.

      Helpful?

  6. How does azoxymethane act to cause cancers?

    1 answer

    1. Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

      Helpful?

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    1 answer

    1. No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  10. What solvents can be used to dissolve Azoxymethane?

    1 answer

    1. Azoxymethane is soluble in water, ether, ethanol, and chloroform. The reported solubility in chlorform is 200 mg/mL, and in water is 100 mg/mL.

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1–10 of 11 Questions  

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