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Merck

A4687

Sigma-Aldrich

Amiprilose hydrochloride

Synonym(e):

1,2-O-Isopropylidene-3-O-[3′-(N,N-dimethylamino)propyl]-α-D-glucofuranose hydrochloride

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About This Item

Empirische Formel (Hill-System):
C14H27NO6 · HCl
CAS-Nummer:
Molekulargewicht:
341.83
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:

Lagertemp.

2-8°C

SMILES String

Cl[H].[H][C@@]1(O[C@@H]2OC(C)(C)O[C@@H]2[C@H]1OCCCN(C)C)[C@H](O)CO

Biochem./physiol. Wirkung

A synthetic carbohydrate shown to be a immunomodulator and anti-viral agent. Used as therapeutic agent in inflammatory arthritis. Regulatory effects on cytokines have been demonstrated in vitro. In vivo treatment of mice results in modulation of eicosanoid synthesis in part through the regulation of PLA2 activity.

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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C E Brinckerhoff
Agents and actions, 30(3-4), 322-328 (1990-06-01)
Amiprilose hydrochloride, a modified hexose sugar effectively decreases proliferation of human skin and synovial fibroblasts and of rabbit synovial fibroblasts. It also decreases production of the inflammatory mediator prostaglandin E2 (PGE2) by these cells. Cell proliferation, measured by incorporation of
W G Riskin et al.
Annals of internal medicine, 111(6), 455-465 (1989-09-15)
To assess the safety and efficacy of amiprilose hydrochloride (HCl), a novel synthetic carbohydrate with anti-inflammatory and immunomodulatory properties, in patients with rheumatoid arthritis. Prospective, multicenter, randomized, parallel group, double-blind placebo-controlled 12-week trial. Two hundred and one functional class I
D H Campen et al.
Arthritis and rheumatism, 31(11), 1358-1364 (1988-11-01)
Levels of interleukin-2 receptors (IL-2R), as measured by a double-antibody "sandwich" enzyme-linked immunosorbent assay technique, were markedly elevated in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis, and bacterial endocarditis, but not in patients with acute gout. Serum
S T Wu et al.
Journal of chromatography. B, Biomedical sciences and applications, 692(1), 149-156 (1997-04-25)
A reversed-phase HPLC method to quantify amiprilose in human plasma is described. The method involves liquid-liquid extraction of amiprilose and the internal standard from plasma. The extracted compounds are derivatized with 1,8-naphthalic dicarboxylic acid using 2-chloro-1-methylpyridinium iodide as a coupling
J M Goldsmith et al.
Journal of immunopharmacology, 8(1), 1-14 (1986-01-01)
Patients with the acquired immunodeficiency syndrome (AIDS) are susceptible to a variety of opportunistic pathogens which require intact cellular immunity for control and eradication. We evaluated interleukin 1 and 2 production in 12 homosexual men without AIDS but with evidence

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