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42129

Lathosterolamid MGI-39

≥97.0% (HPLC)

Synonym(e):

(3S,20S)-20-N-(2-Methylpropyl)-carbamoylpregn-7-en-3β-ol, (3S,20S)-3β-Hydroxy-N-(2-methylpropyl)-7-pregnen-20-carboxamid, Lathosteroloxidase Inhibitor

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About This Item

Empirische Formel (Hill-System):
C26H43NO2
CAS-Nummer:
1058719-76-8
Molekulargewicht:
401.63
MDL-Nummer:
MFCD12912383
UNSPSC-Code:
12352204
PubChem Substanz-ID:
329756194

Biologische Quelle

synthetic

Assay

≥97.0% (HPLC)

Form

crystals and lumps

Lagertemp.

2-8°C

SMILES String

CC(C)CNC(=O)[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H43NO2/c1-16(2)15-27-24(29)17(3)21-8-9-22-20-7-6-18-14-19(28)10-12-25(18,4)23(20)11-13-26(21,22)5/h7,16-19,21-23,28H,6,8-15H2,1-5H3,(H,27,29)/t17-,18-,19-,21+,22-,23-,25-,26+/m0/s1

InChIKey

HUMXZYXRXDDZOG-LFZVSNMSSA-N

Biochem./physiol. Wirkung

Lathosterolamide MGI-39 is an inhibitor of lathosterol oxidase which converts 5-α-cholest-7-en-3-β-ol to cholesta-5,7-dien-3β-ol.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Piktogramme

Exclamation markEnvironment
GHS07,GHS09

Signalwort

Warning

H-Sätze

H302,H400

P-Sätze

P273

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Acute 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Martin Giera et al.
Steroids, 73(3), 299-308 (2008-01-01)
Inhibition of cholesterol biosynthesis offers the opportunity for treatment of cardiovascular diseases. Numerous enzymes are involved in the post-squalene part of this biosynthesis, and selective inhibitors for almost all of the enzymes involved there have been described in literature. The
Ralf Klingenstein et al.
Journal of neurochemistry, 98(3), 748-759 (2006-06-06)
Prion diseases are invariably fatal, neurodegenerative diseases transmitted by an infectious agent, PrPSc, a pathogenic, conformational isoform of the normal prion protein (PrPC). Heterocyclic compounds such as acridine derivatives like quinacrine abolish prion infectivity in a cell culture model of
Ken'ichi Hagiwara et al.
Biological & pharmaceutical bulletin, 30(4), 835-838 (2007-04-06)
In prion diseases, the normal cellular form of prion protein (PrP(C)) is converted into the disease-associated isoforms (PrP(Sc)) which accumulate in the infected tissues. Although the precise mechanism of this conversion remains unsolved, drugs of various categories have been reported
Carlos Fernández et al.
Journal of lipid research, 46(5), 920-929 (2005-02-03)
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes. The aim of the present study was to elucidate the stringency
Carolina C Sánchez-Martín et al.
Cancer research, 67(7), 3379-3386 (2007-04-06)
Cholesterol metabolism is particularly active in malignant, proliferative cells, whereas cholesterol starvation has been shown to inhibit cell proliferation. Inhibition of enzymes involved in cholesterol biosynthesis at steps before the formation of 7-dehydrocholesterol has been shown to selectively affect cell
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