358R-1

MUM1 (EP190) Rabbit Monoclonal Primary Antibody

• Synonym(e): Multiple Myeloma Oncogene-1
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100; 500
• Konjugat: unconjugated
• Antikörperform: culture supernatant
• Antikörper-Produkttyp: primary antibodies
• Klon: EP190, monoclonal
• Beschreibung: For In Vitro Diagnostic Use in Select Regions
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Verpackung: vial of 0.1 mL concentrate (358R-14); vial of 0.1 mL concentrate Research Use Only (358R-14-RUO); vial of 0.5 mL concentrate (358R-15); vial of 1.0 mL concentrate (358R-16); vial of 1.0 mL concentrate Research Use Only (358R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (358R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (358R-17); vial of 7.0 mL pre-dilute ready-to-use (358R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (358R-18-RUO)
• Hersteller/Markenname: Cell Marque^®
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• Isotyp: IgG
• Kontrolle: diffuse large B-cell (lymphoma), plasma cell myeloma (tumor), tonsil
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Visualisierung: cytoplasmic, nuclear
• Angaben zum Gen: human ... PWWP3A(84939)

Beschreibung

Allgemeine Beschreibung

Anti-MUM1 antibody labels a 50kDa, multiple myeloma oncogene-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene.[1][2] It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of germinal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas).[1][2] MUM1 expression has been described in diffuse large B-cell lymphoma (DLBCL).[3] Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma/leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma.[4][3][5] However, the tumor cells in nodular lymphocyte predominant Hodgkin lymphoma are negative or only weakly positive.[6] MUM1 is also expressed in plasma cell myeloma.[7]

Qualität

IVD

IVD

IVD

RUO

Verlinkung

MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: [email protected]

Rechtliche Hinweise

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable